HHLA2

Gene Information

Official Symbol: HHLA2
Official Name: HERV-H LTR-associating 2
Aliases and Previous Symbols: N/A
Entrez ID: 11148
UniProt: Q9UM44
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:23784006}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
RS-1 10μM R08 exp519	-1.96
BML-284 0.09μM R08 exp460	-1.78
CR131-b 0.005μM R08 exp474	-1.77
Fluvastatin 2.2μM R06 exp282	1.8
Bisphenol A 100μM R06 exp269	1.98
Wiskostatin 3μM R07 exp422	2.14

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18943
Expression level (log2 read counts): 2.02

Expression Distribution

V-set
C1-set

positive regulation of activated T cell proliferation
regulation of activated T cell proliferation
T cell costimulation
lymphocyte costimulation
positive regulation of T cell proliferation
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
regulation of T cell proliferation
T cell receptor signaling pathway
positive regulation of T cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
positive regulation of leukocyte cell-cell adhesion
regulation of leukocyte proliferation
positive regulation of cell-cell adhesion
antigen receptor-mediated signaling pathway
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
signaling receptor binding
positive regulation of lymphocyte activation
external side of plasma membrane
regulation of cell-cell adhesion
positive regulation of leukocyte activation
positive regulation of cell adhesion
positive regulation of cell activation
positive regulation of cytokine production
cellular component
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
regulation of lymphocyte activation
immune response-activating signal transduction
immune response-regulating signaling pathway
regulation of leukocyte activation
activation of immune response
regulation of cell activation
regulation of cell adhesion
regulation of cytokine production
molecular function
positive regulation of immune response