HMMR

Entrez Summary: The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008].
UniProt Summary: Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). {ECO:0000250|UniProtKB:Q00547}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epothilone-B 0.0015μM R05 exp231	-2.49
Taxol 0.004μM R03 exp103	-2.48
Mdivi-1 15μM R05 exp217	-2.32
Sulforaphane 9μM R08 exp525	-1.85
Vincristine 0.0005μM R04 exp190	-1.83
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.7
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.71
CyclicAMP 200μM R08 exp475	1.95

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hyaluronan catabolic process
hyaluronic acid binding
hyaluronan metabolic process
glycosaminoglycan catabolic process
aminoglycan catabolic process
mucopolysaccharide metabolic process
microtubule cytoskeleton
glycosaminoglycan metabolic process
aminoglycan metabolic process
carbohydrate derivative catabolic process
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
organic acid catabolic process
carboxylic acid catabolic process
regulation of mitotic cell cycle phase transition
small molecule catabolic process
regulation of cell cycle phase transition
centrosome
cell surface
regulation of mitotic cell cycle
regulation of cell cycle process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
regulation of cell cycle
small molecule metabolic process
organic substance catabolic process
cellular catabolic process
membrane