KANK4

Entrez Summary: N/A
UniProt Summary: May be involved in the control of cytoskeleton formation by regulating actin polymerization.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pyridostatin 4μM R05 exp240	-2.5
Chloramphenicol 2μM R00 exp12	-2.2
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.92
Genistein 15μM R07 exp360	-1.88
Rifampicin 1μM R00 exp31	-1.71
TGF-beta1 44ng/ml R08 exp528	2.35
2-Deoxy-D-glucose 800μM R05 exp214	2.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of actin filament polymerization
negative regulation of protein polymerization
negative regulation of protein complex assembly
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
microtubule cytoskeleton
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
regulation of protein polymerization
regulation of actin filament organization
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
negative regulation of organelle organization
regulation of cellular component size
regulation of actin filament-based process
regulation of protein complex assembly
regulation of anatomical structure size
regulation of cytoskeleton organization
negative regulation of cellular component organization
regulation of cellular component biogenesis
regulation of organelle organization