KIAA0141

Entrez Summary: N/A
UniProt Summary: Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation. {ECO:0000269|PubMed:20563667}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PF-06409577 20μM R07 exp389	1.7
Thapsigargin 0.005μM R07 exp407	1.71
VER-155008 3.9μM R06 exp301	1.74
Calcium Ionophore 0.4μM R07 exp342	1.78
Pimelic-diphenylamide-106 5μM R00 exp28	1.88
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.1
All-trans-Retinoic-Acid 40μM R07 exp334	2.13

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

extrinsic apoptotic signaling pathway via death domain receptors
extrinsic apoptotic signaling pathway
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
apoptotic signaling pathway
regulation of endopeptidase activity
regulation of peptidase activity
regulation of proteolysis
apoptotic process
programmed cell death
cell death
mitochondrion
regulation of hydrolase activity
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death