KLF13

Gene Information

Official Symbol: KLF13
Official Name: Kruppel like factor 13
Aliases and Previous Symbols: N/A
Entrez ID: 51621
UniProt: Q9Y2Y9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells. {ECO:0000269|PubMed:11477107}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
RO-3307 4.7μM R02 exp80	1.7
CR131-b 0.005μM R08 exp474	1.73
Olaparib 4μM R08 exp512	1.76
JQ1 0.8μM R08 exp435	1.78
Methotrexate 0.01μM R08 exp501	1.87
Aphidicolin 0.4μM R08 exp440	1.88
LY2090314 0.003μM R08 exp500 no dilution day6	1.97
TRAIL 5ng/ml R00 exp35	2.08
Ethanol 0.01 R05 exp234	2.3
LY2090314 0.003μM R08 exp499	2.79

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3790
Expression level (log2 read counts): 7.18

Expression Distribution

Gene	Correlation
LAMTOR2	0.451
MLST8	0.439
KLF16	0.405

negative regulation of erythrocyte differentiation
regulation of erythrocyte differentiation
negative regulation of myeloid cell differentiation
negative regulation of hemopoiesis
regulation of myeloid cell differentiation
negative regulation of immune system process
DNA-binding transcription activator activity, RNA polymerase II-specific
regulation of hemopoiesis
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
negative regulation of cell population proliferation
negative regulation of cell differentiation
negative regulation of developmental process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of multicellular organismal process
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of cell population proliferation
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of immune system process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
regulation of cell differentiation
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
gene expression
positive regulation of biosynthetic process