LRRTM3

Entrez Summary: N/A
UniProt Summary: Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mubritinib 0.2μM R02 exp65	-1.78
VE-822 0.04μM R06 exp300	1.73
Dimethyloxaloylglycine 11μM R07 exp314	1.77
BRD2 inhibitor II 20μM R07 exp341	1.86
Pomalidomide 20μM R07 exp391	1.96

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

LRRNT
LRR 4

positive regulation of amyloid-beta formation
positive regulation of amyloid precursor protein catabolic process
presynapse assembly
presynapse organization
regulation of amyloid-beta formation
regulation of amyloid precursor protein catabolic process
integral component of postsynaptic density membrane
positive regulation of synapse assembly
synapse assembly
regulation of synapse assembly
positive regulation of cellular amide metabolic process
regulation of synapse organization
regulation of synapse structure or activity
extracellular matrix
synapse organization
glutamatergic synapse
regulation of cellular amide metabolic process
positive regulation of cellular component biogenesis
positive regulation of nervous system development
cell junction
regulation of nervous system development
regulation of cellular component biogenesis
positive regulation of cellular component organization
positive regulation of developmental process
extracellular space
positive regulation of protein metabolic process
positive regulation of multicellular organismal process