LSS

Entrez Summary: The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009].
UniProt Summary: Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. {ECO:0000269|PubMed:26200341, ECO:0000269|PubMed:7639730}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lanosterol synthase activity
triterpenoid biosynthetic process
beta-amyrin synthase activity
triterpenoid metabolic process
terpenoid biosynthetic process
isoprenoid biosynthetic process
cholesterol biosynthetic process
regulation of cholesterol biosynthetic process
secondary alcohol biosynthetic process
regulation of sterol biosynthetic process
sterol biosynthetic process
regulation of cholesterol metabolic process
regulation of alcohol biosynthetic process
lipid droplet
regulation of steroid biosynthetic process
alcohol biosynthetic process
regulation of steroid metabolic process
cholesterol metabolic process
terpenoid metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
sterol metabolic process
isoprenoid metabolic process
organic hydroxy compound biosynthetic process
regulation of lipid biosynthetic process
steroid metabolic process
regulation of protein stability
alcohol metabolic process
regulation of lipid metabolic process
regulation of small molecule metabolic process
organic hydroxy compound metabolic process
lipid biosynthetic process
small molecule biosynthetic process
endoplasmic reticulum membrane
cellular lipid metabolic process
lipid metabolic process
organic cyclic compound biosynthetic process
small molecule metabolic process
membrane