MAFF

Entrez Summary: N/A
UniProt Summary: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:8932385, PubMed:16549056). May be a transcriptional enhancer in the up- regulation of the oxytocin receptor gene at parturition (PubMed:10527846). {ECO:0000269|PubMed:10527846, ECO:0000269|PubMed:16549056, ECO:0000269|PubMed:8932385}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

parturition
skeletal muscle cell differentiation
regulation of epidermal cell differentiation
regulation of epidermis development
skeletal muscle tissue development
skeletal muscle organ development
regulation of epithelial cell differentiation
multi-multicellular organism process
striated muscle tissue development
blood coagulation
coagulation
muscle organ development
muscle tissue development
hemostasis
in utero embryonic development
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
muscle structure development
wound healing
transcription by RNA polymerase II
regulation of body fluid levels
RNA polymerase II proximal promoter sequence-specific DNA binding
response to wounding
chordate embryonic development
transcription, DNA-templated
nucleic acid-templated transcription
embryo development ending in birth or egg hatching
RNA biosynthetic process
DNA-binding transcription factor activity
embryo development
multi-organism reproductive process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
mitochondrion
organic cyclic compound biosynthetic process
reproductive process
reproduction
positive regulation of transcription, DNA-templated