MAGEA3

Gene Information

Official Symbol: MAGEA3
Official Name: MAGE family member A3
Aliases and Previous Symbols: N/A
Entrez ID: 4102
UniProt: P43357
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008].
UniProt Summary: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:20864041}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18627
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.87
BI-2536 0.001μM R01 exp41	-1.78
Benzoate 10000μM R08 exp455	1.73

MAGE N
MAGE

caspase binding
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of protein maturation
negative regulation of protein processing
negative regulation of response to endoplasmic reticulum stress
regulation of protein processing
regulation of protein maturation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of response to endoplasmic reticulum stress
negative regulation of cysteine-type endopeptidase activity
negative regulation of intrinsic apoptotic signaling pathway
regulation of intrinsic apoptotic signaling pathway
regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of apoptotic signaling pathway
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of proteolysis
regulation of apoptotic signaling pathway
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
negative regulation of intracellular signal transduction
regulation of proteolysis
regulation of cellular response to stress
negative regulation of catalytic activity
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
endoplasmic reticulum
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
negative regulation of signal transduction
regulation of hydrolase activity
negative regulation of cell communication
negative regulation of signaling
regulation of response to stress
regulation of apoptotic process