MANBA

Entrez Summary: This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement. [provided by RefSeq, Jul 2008].
UniProt Summary: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.72
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.79
2-Methoxyestradiol 0.2μM R01 exp40	1.82
YM155 0.0002μM R01 exp61	1.9
GSK-LSD1 10μM R03 exp123	2.05

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Glyco hydro 2 N
Glyco hydro 2 C

cell wall polysaccharide catabolic process
beta-mannosidase activity
mannan metabolic process
mannan catabolic process
cell wall polysaccharide metabolic process
cell wall macromolecule catabolic process
cell wall macromolecule metabolic process
cell wall organization or biogenesis
oligosaccharide catabolic process
cellular polysaccharide catabolic process
polysaccharide catabolic process
mannose binding
glycoprotein catabolic process
cellular carbohydrate catabolic process
oligosaccharide metabolic process
azurophil granule membrane
cellular polysaccharide metabolic process
polysaccharide metabolic process
lysosomal lumen
carbohydrate catabolic process
cellular carbohydrate metabolic process
carbohydrate derivative catabolic process
lysosome
glycoprotein metabolic process
carbohydrate metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
protein catabolic process
intracellular membrane-bounded organelle
regulated exocytosis
leukocyte mediated immunity