MARK1

Entrez Summary: N/A
UniProt Summary: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidic acid binding
tau-protein kinase activity
establishment of mitochondrion localization
tau protein binding
mitochondrion localization
phosphatidylserine binding
phosphatidylinositol-4,5-bisphosphate binding
neuron migration
regulation of dendrite development
microtubule cytoskeleton
peptidyl-serine phosphorylation
peptidyl-serine modification
magnesium ion binding
Wnt signaling pathway
cell-cell signaling by wnt
establishment of organelle localization
protein serine/threonine kinase activity
cytoskeleton
dendrite
cell surface receptor signaling pathway involved in cell-cell signaling
microtubule cytoskeleton organization
regulation of neuron projection development
organelle localization
regulation of neuron differentiation
microtubule-based process
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of neurogenesis
peptidyl-amino acid modification
regulation of nervous system development
regulation of cell development
cell migration
protein phosphorylation
cell motility
localization of cell
cytoskeleton organization
cell-cell signaling
phosphorylation
locomotion
ATP binding