MCM8

Official Symbol: MCM8
Official Name: minichromosome maintenance 8 homologous recombination repair factor
Aliases and Previous Symbols: N/A
Entrez ID: 84515
UniProt: Q9UJA3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Campthothecin 0.001μM R06 exp270	-3.3
Rucaparib 6.5μM R08 exp520	-2.72
Diepoxybutane 3μM R07 exp354	-2.3
Genistein 15μM R07 exp360	-2.23
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.1
Olaparib 4μM R08 exp512	-2.05
Pyridostatin 4μM R05 exp240	-2.02
A-395N 10μM R05 exp219	-2
Lead acetate 2000μM R08 exp498 no dilution day6	-1.97
Docosahexaenoic-acid 50μM R07 exp356	-1.93
Metformin 100 to 150μM on day4 R04 exp170	-1.89
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.89
Temozolomide 200μM R04 exp189	-1.86
Ethanol 0.003 R08 exp437	-1.8
Lapatinib 5μM R01 exp47	-1.79
Quercetin 20μM R08 exp517	-1.79
UMK57 1μM R01 exp59	-1.75
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.71
GSK-J4 1-1.25μM to day4 R07 exp363	1.75

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

MCM
AAA 5

recombinational interstrand cross-link repair
MCM8-MCM9 complex
MutLbeta complex binding
MutSbeta complex binding
MutSalpha complex binding
MCM complex
protein localization to chromatin
DNA replication origin binding
interstrand cross-link repair
DNA helicase activity
protein localization to chromosome
double-strand break repair via homologous recombination
recombinational repair
single-stranded DNA binding
DNA duplex unwinding
DNA geometric change
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
chromosome
female gamete generation
protein stabilization
double-strand break repair
DNA replication
DNA recombination
mitotic cell cycle phase transition
cell cycle phase transition
regulation of protein stability
DNA conformation change
enzyme binding
chromatin binding
DNA repair
male gamete generation
mitotic cell cycle process
mitotic cell cycle
gamete generation
protein localization to organelle
DNA metabolic process
cellular response to DNA damage stimulus
multicellular organismal reproductive process
sexual reproduction