MIA2
Gene Information
- Official Symbol: MIA2
- Official Name: MIA SH3 domain ER export factor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 4253
- UniProt: Q96PC5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016].
- UniProt Summary: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Isoform 1 plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:27138255}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16513
- Expression level (log2 read counts): 0.24
MIA2 Expression in NALM6 Cells: 0.24
