MICU1

Entrez Summary: This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Radicicol 0.16μM R05 exp242	1.74
Dimethyloxaloylglycine 100μM R05 exp229	1.77
CB-5083 0.4μM R08 exp468	1.99
ABT-702 5μM R06 exp261	2.1
Parthenolide 2.5μM R05 exp238	2.12
Calcium Ionophore 0.4μM R07 exp342	3.77

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
RRM1	0.468
HARS	0.413

regulation of response to salt stress
regulation of cellular hyperosmotic salinity response
uniplex complex
integral component of mitochondrial membrane
calcium import into the mitochondrion
regulation of cellular response to osmotic stress
positive regulation of mitochondrial calcium ion concentration
regulation of response to osmotic stress
mitochondrial calcium ion transmembrane transport
calcium channel complex
mitochondrial calcium ion homeostasis
calcium ion import
mitochondrial intermembrane space
intracellular
cytosolic calcium ion transport
mitochondrial transmembrane transport
calcium ion transmembrane transport
mitochondrial transport
calcium ion transport
divalent metal ion transport
divalent inorganic cation transport
protein homooligomerization
mitochondrial inner membrane
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
protein heterodimerization activity
divalent inorganic cation homeostasis
protein complex oligomerization
cellular metal ion homeostasis
inorganic cation transmembrane transport
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
cation homeostasis
inorganic ion homeostasis
calcium ion binding