MYBL2

Entrez Summary: N/A
UniProt Summary: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BML-284 0.09μM R08 exp460	-2.58
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.06
DABN 20μM R00 exp17	-2.05
Doxorubicin 0.02μM R08 exp478	-1.97
Demecolcine 0.03μM R05 exp228	-1.96
Colchicine 0.009μM R05 exp215	-1.91
BI-D1870 3.15μM R02 exp66	-1.86
Epigallocatechin gallate 20μM R05 exp230	-1.84
GSK461364A 0.005μM R03 exp125	-1.77
Vinblastine 0.2μM R03 exp108	-1.77
GSK-J4 1.5μM R08 exp441	-1.74
BI-6727 0.001μM R01 exp42	1.72
MLN-4924 0.2μM R00 exp21	1.74
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.77
All-trans-Retinoic-Acid 8μM R07 exp333	1.78
Chloroquine 32μM R08 exp470	1.8
Dimethyloxaloylglycine 11μM R07 exp314	1.83
Tunicamycin 0.04μM R07 exp418	1.91
Etoposide 0.1μM R05 exp198	2

Global Fraction of Cell Lines Where Essential: 97/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	10/28
bone	1/26
breast	7/33
central nervous system	4/56
cervix	1/4
colorectal	4/17
esophagus	4/13
fibroblast	0/1
gastric	4/16
kidney	0/21
liver	0/20
lung	10/75
lymphocyte	3/16
ovary	2/26
pancreas	1/24
peripheral nervous system	3/16
plasma cell	0/15
prostate	1/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	4/29
uterus	0/5

Expression Distribution

Gene	Correlation
CKAP5	0.416
CENPP	0.401

Cmyb C
Myb DNA-binding

Myb complex
mitotic spindle assembly
positive regulation of neuron apoptotic process
mitotic spindle organization
positive regulation of neuron death
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
spindle assembly
microtubule cytoskeleton organization involved in mitosis
mitotic nuclear division
spindle organization
regulation of neuron apoptotic process
nuclear division
regulation of neuron death
organelle fission
DNA-binding transcription activator activity, RNA polymerase II-specific
microtubule cytoskeleton organization
RNA polymerase II proximal promoter sequence-specific DNA binding
mitotic cell cycle process
positive regulation of apoptotic process
positive regulation of programmed cell death
microtubule-based process
DNA-binding transcription factor activity
mitotic cell cycle
positive regulation of cell death
organelle assembly
cell cycle process
cellular response to cytokine stimulus
response to cytokine
cytoskeleton organization
regulation of cell cycle
positive regulation of transcription by RNA polymerase II
cell cycle
regulation of apoptotic process
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of programmed cell death
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of cell death