NAV3

Gene Information

Official Symbol: N/AV3
Official Name: neuron navigator 3
Aliases and Previous Symbols: N/A
Entrez ID: 89795
UniProt: Q8IVL0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May regulate IL2 production by T-cells. May be involved in neuron regeneration. {ECO:0000269|PubMed:16166283}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3926
Expression level (log2 read counts): 3.48

Expression Distribution

Screen	Score
A-366 10μM R03 exp115	1.74
Chlorpromazine 10μM R07 exp344	1.74
Epothilone-B 0.0015μM R05 exp231	1.77
YM155 0.001μM R08 exp432	1.85

positive regulation of invadopodium disassembly
regulation of invadopodium disassembly
microtubule end
negative regulation of interleukin-2 production
nuclear outer membrane
negative regulation of microtubule depolymerization
regulation of microtubule depolymerization
positive regulation of microtubule polymerization
positive regulation of microtubule polymerization or depolymerization
negative regulation of microtubule polymerization or depolymerization
regulation of microtubule polymerization
regulation of interleukin-2 production
negative regulation of protein depolymerization
negative regulation of protein complex disassembly
regulation of microtubule polymerization or depolymerization
regulation of protein depolymerization
regulation of protein complex disassembly
positive regulation of protein polymerization
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
regulation of microtubule cytoskeleton organization
positive regulation of supramolecular fiber organization
positive regulation of cytoskeleton organization
regulation of microtubule-based process
regulation of protein polymerization
microtubule binding
positive regulation of protein complex assembly
negative regulation of cell migration
negative regulation of cytokine production
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
regulation of supramolecular fiber organization
negative regulation of organelle organization
positive regulation of cell projection organization
regulation of protein complex assembly
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
positive regulation of organelle organization
regulation of plasma membrane bounded cell projection organization