NBAS

Entrez Summary: This gene encodes a protein with two leucine zipper domains, a ribosomal protein S14 signature domain and a Sec39 like domain. The protein is thought to be involved in Golgi-to-ER transport. Mutations in this gene are associated with short stature, optic nerve atrophy, and Pelger-Huet anomaly. [provided by RefSeq, Oct 2012].
UniProt Summary: Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). {ECO:0000269|PubMed:19369418, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-2.22
Dinaciclib 0.007μM R07 exp355	-2.21
Ribavirin 10μM R01 exp52	-2.2
SB202190 10μM R03 exp148	-1.93
Nifuroxazide 1μM R01 exp51	-1.89
ML-792 0.2μM R08 exp505	-1.84
Lapatinib 5μM R01 exp47	-1.7
TRAIL 50ng/ml R00 exp36	1.86
Phenformin 20μM R03 exp143	1.96

Global Fraction of Cell Lines Where Essential: 82/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	2/28
blood	1/28
bone	0/26
breast	4/33
central nervous system	10/56
cervix	0/4
colorectal	2/17
esophagus	1/13
fibroblast	1/1
gastric	3/16
kidney	3/21
liver	3/20
lung	6/75
lymphocyte	4/16
ovary	2/26
pancreas	1/24
peripheral nervous system	4/16
plasma cell	4/15
prostate	0/1
skin	0/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	2/29
uterus	0/5

Expression Distribution

Dsl1/NZR complex
negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
negative regulation of mRNA catabolic process
negative regulation of RNA catabolic process
SNARE binding
negative regulation of mRNA metabolic process
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
nuclear-transcribed mRNA catabolic process
regulation of mRNA catabolic process
mRNA catabolic process
RNA catabolic process
negative regulation of cellular catabolic process
negative regulation of catabolic process
regulation of mRNA metabolic process
Golgi vesicle transport
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
mRNA metabolic process
regulation of cellular catabolic process
cellular macromolecule catabolic process
endoplasmic reticulum membrane
regulation of catabolic process
endoplasmic reticulum
macromolecule catabolic process
negative regulation of RNA metabolic process
negative regulation of nucleobase-containing compound metabolic process
protein transport
peptide transport
amide transport
establishment of protein localization
RNA metabolic process
negative regulation of gene expression
organic substance catabolic process
cellular catabolic process
nitrogen compound transport
vesicle-mediated transport