NLRP7

Gene Information

Official Symbol: NLRP7
Official Name: NLR family pyrin domain containing 7
Aliases and Previous Symbols: N/A
Entrez ID: 199713
UniProt: Q8WX94
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: Inhibits CASP1/caspase-1-dependent IL1B secretion. {ECO:0000269|PubMed:15817483}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3532
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.75
Cidofovir 10μM R07 exp345	1.84
35°C R06 exp302	2.1
BML-284 0.09μM R08 exp460	2.21

PAAD DAPIN
NACHT

negative regulation of aspartic-type peptidase activity
aspartic-type endopeptidase inhibitor activity
interleukin-1 binding
regulation of aspartic-type peptidase activity
caspase binding
negative regulation of interleukin-1 beta secretion
negative regulation of cytokine production involved in inflammatory response
negative regulation of interleukin-1 secretion
negative regulation of interleukin-1 beta production
positive regulation of interleukin-1 beta secretion
negative regulation of protein processing
negative regulation of protein maturation
negative regulation of interleukin-1 production
positive regulation of interleukin-1 secretion
regulation of cytokine production involved in inflammatory response
regulation of interleukin-1 beta secretion
positive regulation of interleukin-1 beta production
regulation of interleukin-1 secretion
positive regulation of interleukin-1 production
regulation of protein processing
negative regulation of cytokine secretion
regulation of protein maturation
regulation of interleukin-1 beta production
regulation of interleukin-1 production
negative regulation of protein secretion
negative regulation of inflammatory response
negative regulation of peptide secretion
positive regulation of cytokine secretion
cellular response to interleukin-1
negative regulation of protein transport
cellular response to lipopolysaccharide
negative regulation of establishment of protein localization
cellular response to molecule of bacterial origin
response to interleukin-1
negative regulation of secretion by cell
regulation of cytokine secretion
negative regulation of defense response
cellular response to biotic stimulus
negative regulation of secretion
negative regulation of endopeptidase activity