NR2C2

Entrez Summary: N/A
UniProt Summary: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Clomiphene 4.4μM R02 exp68	-3.09
Methotrexate 0.01μM R08 exp501	-2.44
Aminopterin 0.005μM R07 exp335	-2.29
2-Deoxy-D-glucose 800μM R05 exp214	-2.28
Vemurafenib 6.6μM R08 exp434	-2.16
Vemurafenib 6.6μM R02 exp89	-1.95
Bafilomycin-A1 0.009μM R08 exp454	-1.87
Dimethyloxaloylglycine 100μM R05 exp229	-1.87
Oligomycin-A 2μM R00 exp25	-1.84
LY2090314 0.003μM R08 exp499	1.76
5-Fluorouracil 2μM R00 exp1	1.97
LY2090314 0.003μM R08 exp500 no dilution day6	2.2

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Hormone recep
zf-C4

positive regulation of embryonic development
steroid hormone receptor activity
steroid hormone mediated signaling pathway
regulation of embryonic development
hormone-mediated signaling pathway
transcription initiation from RNA polymerase II promoter
cellular response to steroid hormone stimulus
signaling receptor activity
DNA-templated transcription, initiation
transcription coactivator activity
RNA polymerase II regulatory region sequence-specific DNA binding
response to steroid hormone
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
protein heterodimerization activity
RNA polymerase II proximal promoter sequence-specific DNA binding
cellular response to lipid
cellular response to organic cyclic compound
spermatogenesis
male gamete generation
cellular response to hormone stimulus
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
gamete generation
multicellular organismal reproductive process
sexual reproduction
zinc ion binding
multicellular organism reproduction
response to lipid
response to hormone
response to organic cyclic compound
multi-organism reproductive process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
cellular response to endogenous stimulus