NSA2

Entrez Summary: N/A
UniProt Summary: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hippuristanol 0.12μM R08 exp488	-2.26
Chloramphenicol 2μM R00 exp12	1.74
Rapamycin 1μM R00 exp29	1.87
Menadione 5μM R06 exp292	1.92
Ethanol 0.003 R08 exp437	1.96
Nifurtimox 1μM R03 exp141	2.12
Nocodazole 0.02μM R00 exp23	2.43
Bortezomib 0.005μM R00 exp6	2.53
Pimelic-diphenylamide-106 0.5μM R00 exp27	2.79

Global Fraction of Cell Lines Where Essential: 434/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	17/28
blood	19/28
bone	18/26
breast	22/33
central nervous system	40/56
cervix	3/4
colorectal	10/17
esophagus	6/13
fibroblast	0/1
gastric	14/16
kidney	13/21
liver	10/20
lung	45/75
lymphocyte	10/16
ovary	16/26
pancreas	10/24
peripheral nervous system	10/16
plasma cell	6/15
prostate	1/1
skin	9/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	15/22
urinary tract	16/29
uterus	3/5

Expression Distribution

preribosome, large subunit precursor
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
gene expression