NXF1

Entrez Summary: N/A
UniProt Summary: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:9660949}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.04μM R03 exp98	-1.94
DABN racemic mixture R03 exp93	-1.79
Ethanol 0.003 R08 exp437	1.7
JQ1 0.01μM R03 exp130	1.73
Disulfiram 4.3μM R06 exp281	1.74
Metformin 100 to 150μM on day4 R04 exp170	1.8
L-74142 5μM R03 exp131	1.83
SB203580 25μM R03 exp149	1.92
Rucaparib 6.5μM R08 exp520	2.03
Betulinic acid 10 to 15μM on day4 R05 exp222	2.08
Momordin-Ic 10μM R08 exp506	2.3
Cisplatin 0.35μM R06 exp273	2.33

Global Fraction of Cell Lines Where Essential: 523/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	22/28
blood	25/28
bone	13/26
breast	24/33
central nervous system	38/56
cervix	3/4
colorectal	12/17
esophagus	10/13
fibroblast	0/1
gastric	11/16
kidney	12/21
liver	14/20
lung	49/75
lymphocyte	11/16
ovary	21/26
pancreas	18/24
peripheral nervous system	11/16
plasma cell	12/15
prostate	1/1
skin	20/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	14/22
urinary tract	20/29
uterus	4/5

Expression Distribution

nuclear inclusion body
transcription export complex
poly(A)+ mRNA export from nucleus
nuclear pore
mRNA export from nucleus
mRNA-containing ribonucleoprotein complex export from nucleus
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
protein export from nucleus
mRNA transport
nuclear export
mRNA binding
nucleic acid transport
RNA transport
establishment of RNA localization
RNA localization
nucleobase-containing compound transport
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
nuclear speck
viral process
symbiotic process
interspecies interaction between organisms
intracellular protein transport
RNA binding
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
gene expression