OMA1

Entrez Summary: N/A
UniProt Summary: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. {ECO:0000250|UniProtKB:Q9D8H7, ECO:0000269|PubMed:20038677}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK-J4 1μM R07 exp362	-2.04
Vitamin-D3 40μM R08 exp536	1.76
BI-D1870 3.15μM R02 exp66	1.78
Calcium Ionophore 0.4μM R07 exp342	1.78
Rapamycin 1μM R00 exp29	1.8
Dimethyl-Sulfoxide 1pc R03 exp120	1.82
Bisphenol A 100μM R06 exp269	1.84
HMS-I2 10μM R06 exp288	1.97
LLY-283 2.6μM R06 exp290	2.27
iCRT14 30μM R08 exp492	2.95
All-trans-Retinoic-Acid 40μM R07 exp334	3.25
UM0129480 7μM R02 exp85	3.25
Oligomycin-A 2μM R00 exp25	8.37

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of mitochondrial fusion
regulation of mitochondrial fusion
mitochondrial protein processing
diet induced thermogenesis
adaptive thermogenesis
response to dietary excess
protein quality control for misfolded or incompletely synthesized proteins
cristae formation
energy homeostasis
inner mitochondrial membrane organization
negative regulation of mitochondrion organization
positive regulation of cold-induced thermogenesis
mitochondrial membrane
metalloendopeptidase activity
glucose metabolic process
mitochondrial membrane organization
regulation of cold-induced thermogenesis
hexose metabolic process
protein processing
regulation of mitochondrion organization
monosaccharide metabolic process
protein maturation
multicellular organismal homeostasis
negative regulation of organelle organization
mitochondrial inner membrane
mitochondrion organization
carbohydrate metabolic process
response to nutrient levels
response to extracellular stimulus
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
negative regulation of cellular component organization
membrane organization
cellular macromolecule catabolic process
negative regulation of developmental process
macromolecule catabolic process
organonitrogen compound catabolic process
regulation of anatomical structure morphogenesis
lipid metabolic process