PC

Entrez Summary: This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mubritinib 0.2μM R01 exp48	-3.02
Nifuroxazide 5μM R03 exp102	-2.36
Benzoate 10000μM R08 exp455	-1.91
QNZ 0.01μM R08 exp439	-1.82
Chloroquine 32μM R08 exp470	-1.75
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.72
Pyridostatin 4μM R05 exp240	1.82

Global Fraction of Cell Lines Where Essential: 18/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	1/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	1/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	1/29
uterus	0/5

Expression Distribution

pyruvate carboxylase activity
viral genome packaging
viral RNA genome packaging
positive regulation by host of viral release from host cell
biotin binding
modulation by host of viral release from host cell
biotin metabolic process
positive regulation of viral release from host cell
positive regulation by host of viral process
modulation by host of viral process
regulation of viral release from host cell
virion assembly
gluconeogenesis
hexose biosynthetic process
monosaccharide biosynthetic process
positive regulation of viral life cycle
pyruvate metabolic process
modification by host of symbiont morphology or physiology
interaction with symbiont
water-soluble vitamin metabolic process
positive regulation of viral process
modification of morphology or physiology of other organism involved in symbiotic interaction
glucose metabolic process
vitamin metabolic process
carbohydrate biosynthetic process
regulation of viral life cycle
modification of morphology or physiology of other organism
hexose metabolic process
monosaccharide metabolic process
viral life cycle
regulation of viral process
regulation of symbiosis, encompassing mutualism through parasitism
coenzyme metabolic process
sulfur compound metabolic process
mitochondrial matrix
cofactor metabolic process
carbohydrate metabolic process
drug metabolic process
positive regulation of multi-organism process
monocarboxylic acid metabolic process