PEX16

Entrez Summary: The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described. [provided by RefSeq, Jul 2008].
UniProt Summary: Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:12223482, ECO:0000269|PubMed:16717127}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MLN-4924 2μM R00 exp22	-1.77
Latrunculin-B 10μM R07 exp374	-1.73
Vincristine 0.0005μM R04 exp190	1.77
CB-5083 0.4μM R08 exp468	1.8
2-Methoxyestradiol 0.55μM R07 exp310	2.08
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.1
Cerivastatin 0.15μM R05 exp226	2.39
Fluvastatin 2.2μM R06 exp282	2.64

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ER-dependent peroxisome organization
ER-dependent peroxisome localization
peroxisome membrane biogenesis
protein to membrane docking
protein import into peroxisome membrane
protein import into peroxisome matrix
integral component of peroxisomal membrane
peroxisomal membrane transport
protein transmembrane import into intracellular organelle
membrane biogenesis
intracellular protein transmembrane transport
peroxisomal membrane
protein transmembrane transport
establishment of protein localization to peroxisome
protein targeting to peroxisome
protein localization to peroxisome
peroxisomal transport
peroxisome organization
peroxisome
protein import
protein targeting to membrane
membrane docking
protein C-terminus binding
establishment of protein localization to membrane
protein targeting
establishment of protein localization to organelle
protein localization to membrane
protein localization to organelle
endoplasmic reticulum membrane
intracellular protein transport
endoplasmic reticulum
transmembrane transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell