PEX6

Entrez Summary: This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
UniProt Summary: Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UNC2400 2μM R03 exp156	-2.35
Alpha-Amanitin 0.5μM R00 exp5	-2.18
Bortezomib 0.05μM R00 exp7	-2.12
Dynasore 10μM R04 exp180	-1.78
Tubacin 1.6μM R07 exp416	-1.78
Brefeldin A 0.02μM R00 exp8	-1.76
Pimelic-diphenylamide-106 0.5μM R00 exp27	-1.72
CFI-400945 25μM R08 exp469	1.73
Amiloride 100μM R08 exp447	1.74
SNS-032 15μM R08 exp443	1.81
CI-1040 9.5μM R08 exp472	1.82
Epigallocatechin gallate 20μM R05 exp230	2.07
MK2206 4μM R08 exp504	2.11
Fluvastatin 2.2μM R06 exp282	2.12
Cerivastatin 0.15μM R05 exp226	3.26

Global Fraction of Cell Lines Where Essential: 13/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	2/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	2/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein import into peroxisome matrix, translocation
photoreceptor cell cilium
protein import into peroxisome matrix
peroxisomal membrane transport
ATPase activity, coupled
protein transmembrane import into intracellular organelle
intracellular protein transmembrane transport
peroxisomal membrane
protein transmembrane transport
photoreceptor outer segment
establishment of protein localization to peroxisome
protein localization to peroxisome
protein targeting to peroxisome
peroxisomal transport
peroxisome organization
peroxisome
protein import
protein stabilization
protein C-terminus binding
ATPase activity
protein-containing complex binding
regulation of protein stability
protein targeting
establishment of protein localization to organelle
protein localization to organelle
intracellular protein transport
transmembrane transport
ATP binding
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport