PFN2

Gene Information

Official Symbol: PFN2
Official Name: profilin 2
Aliases and Previous Symbols: N/A
Entrez ID: 5217
UniProt: P35080
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I2 10μM R06 exp288	-1.83
SGC0946 7μM R03 exp151	-1.81
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	1.71
Nicotine 3000μM R08 exp510	1.74
BI-2536 0.02μM R03 exp96	1.81
SB202190 10μM R03 exp148	1.92
Rifampicin 10μM R00 exp32	1.95
Isonicotinamide 500μM R03 exp129	1.98
MS094 2μM R03 exp136	2.48

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17448
Expression level (log2 read counts): -0.02

Expression Distribution

negative regulation of ruffle assembly
modification of postsynaptic actin cytoskeleton
modification of postsynaptic structure
modification of synaptic structure
negative regulation of plasma membrane bounded cell projection assembly
actin monomer binding
regulation of ruffle assembly
positive regulation of stress fiber assembly
negative regulation of actin filament polymerization
positive regulation of ATPase activity
positive regulation of actin filament bundle assembly
negative regulation of protein polymerization
negative regulation of epithelial cell migration
phosphatidylinositol-4,5-bisphosphate binding
regulation of synaptic vesicle exocytosis
regulation of stress fiber assembly
regulation of ATPase activity
Schaffer collateral - CA1 synapse
postsynapse
regulation of actomyosin structure organization
positive regulation of actin filament polymerization
regulation of actin filament bundle assembly
presynapse
positive regulation of peptidyl-serine phosphorylation
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
positive regulation of protein polymerization
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
regulation of peptidyl-serine phosphorylation
negative regulation of cytoskeleton organization
regulation of neurotransmitter transport
regulation of regulated secretory pathway
regulation of actin filament polymerization
protein stabilization
negative regulation of cell projection organization
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
regulation of plasma membrane bounded cell projection assembly