PGAP1

Entrez Summary: The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this may be an important factor in the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi. Defects in this gene are a cause an autosomal recessive form of cognitive impairment. [provided by RefSeq, Jul 2017].
UniProt Summary: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
PFI-2 4μM R05 exp239	-1.9
Thalidomide 20μM R07 exp406	-1.89
All-trans-Retinoic-Acid 40μM R07 exp334	1.82

phosphatidylinositol deacylase activity
phosphoric ester hydrolase activity
myo-inositol transport
attachment of GPI anchor to protein
hydrolase activity, acting on ester bonds
polyol transport
nuclease activity
forebrain regionalization
GPI anchor biosynthetic process
GPI anchor metabolic process
anterior/posterior axis specification
embryonic pattern specification
glycolipid biosynthetic process
protein lipidation
axis specification
lipoprotein biosynthetic process
phosphatidylinositol biosynthetic process
glycolipid metabolic process
liposaccharide metabolic process
lipoprotein metabolic process
membrane lipid biosynthetic process
organic hydroxy compound transport
sensory perception of sound
sensory perception of mechanical stimulus
phosphatidylinositol metabolic process
membrane lipid metabolic process
glycerophospholipid biosynthetic process
endoplasmic reticulum to Golgi vesicle-mediated transport
anterior/posterior pattern specification
glycerolipid biosynthetic process
phospholipid biosynthetic process
nucleic acid phosphodiester bond hydrolysis
glycerophospholipid metabolic process
regionalization
Golgi vesicle transport
phospholipid metabolic process
glycerolipid metabolic process
forebrain development
pattern specification process
organophosphate biosynthetic process