PHC3

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.73
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.73
CoCl2 18μM R07 exp346	1.76
CB-5083 0.4μM R08 exp468	1.88

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
RRM1	0.59
POLR2J3	0.461

SAM 2
SAM 1

PRC1 complex
PcG protein complex
negative regulation of G0 to G1 transition
regulation of G0 to G1 transition
negative regulation of cell cycle process
negative regulation of cell cycle
regulation of cell cycle process
zinc ion binding
regulation of cell cycle
DNA binding