PKNOX1
Gene Information
- Official Symbol: PKNOX1
- Official Name: PBX/knotted 1 homeobox 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5316
- UniProt: P55347
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Homeobox KN |
| Homeobox |
GO Terms
| erythrocyte differentiation |
| erythrocyte homeostasis |
| myeloid cell homeostasis |
| T cell differentiation |
| homeostasis of number of cells |
| transcription factor complex |
| myeloid cell differentiation |
| T cell activation |
| lymphocyte differentiation |
| camera-type eye development |
| angiogenesis |
| leukocyte differentiation |
| eye development |
| visual system development |
| sensory system development |
| lymphocyte activation |
| blood vessel morphogenesis |
| sequence-specific DNA binding |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| transcription by RNA polymerase II |
| blood vessel development |
| protein heterodimerization activity |
| vasculature development |
| cardiovascular system development |
| sensory organ development |
| hemopoiesis |
| hematopoietic or lymphoid organ development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| immune system development |
| RNA biosynthetic process |
| tube morphogenesis |
| DNA-binding transcription factor activity |
| tube development |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| leukocyte activation |
| cell activation |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| organic cyclic compound biosynthetic process |
| positive regulation of transcription, DNA-templated |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2050
- Expression level (log2 read counts): 4.77
Expression Distribution
PKNOX1 Expression in NALM6 Cells: 4.77
