PLD2

Entrez Summary: The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].
UniProt Summary: May have a role in signal-induced cytoskeletal regulation and/or endocytosis. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PLDc
PX

N-acylphosphatidylethanolamine-specific phospholipase D activity
phospholipase D activity
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
synaptic vesicle recycling
inositol lipid-mediated signaling
phosphatidylinositol binding
presynapse
synaptic vesicle cycle
vesicle-mediated transport in synapse
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
Fc receptor signaling pathway
phospholipid biosynthetic process
lipid catabolic process
glycerophospholipid metabolic process
small GTPase mediated signal transduction
phagocytosis
phospholipid metabolic process
glycerolipid metabolic process
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
organophosphate biosynthetic process
immune response-activating signal transduction
lipid biosynthetic process
immune response-regulating signaling pathway
activation of immune response
positive regulation of immune response
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
Golgi apparatus
localization of cell
cell motility
immune effector process
cytoskeleton organization