PODN

Entrez Summary: The protein encoded by this gene is a member of the small leucine-rich repeat protein family and contains an amino terminal CX3CXCX7C cysteine-rich cluster followed by a leucine-rich repeat domain. Studies suggest that this protein could function to inhibit smooth muscle cell proliferation and migration following arterial injury. [provided by RefSeq, Jul 2016].
UniProt Summary: Negatively regulates cell proliferation and cell migration. {ECO:0000269|PubMed:15063725}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotinamide Riboside 100μM R03 exp139	1.7
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.82
OICR-9429 10μM R03 exp142	1.83
UNC2400 2μM R03 exp156	1.85

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

extracellular matrix structural constituent conferring compression resistance
collagen binding
negative regulation of cell migration
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
collagen-containing extracellular matrix
negative regulation of cell population proliferation
regulation of cell migration
regulation of cell motility
regulation of locomotion
regulation of cellular component movement
extracellular space
regulation of cell population proliferation