POLR2E

Entrez Summary: N/A
UniProt Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 726/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/25
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	14/14
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

RNA pol Rpb5 N
RNA pol Rpb5 C

RNA polymerase II activity
RNA polymerase I activity
RNA polymerase I complex
RNA polymerase II, core complex
RNA polymerase III activity
RNA polymerase III complex
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
DNA-directed 5-3 RNA polymerase activity
7-methylguanosine mRNA capping
RNA capping
7-methylguanosine RNA capping
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
positive regulation of viral transcription
transcription by RNA polymerase III
positive regulation of gene expression, epigenetic
regulation of viral transcription
somatic stem cell population maintenance
snRNA transcription by RNA polymerase II
snRNA transcription
DNA-templated transcription, termination
transcription-coupled nucleotide-excision repair
transcription elongation from RNA polymerase II promoter
positive regulation of type I interferon production
fibroblast growth factor receptor signaling pathway
regulation of gene silencing by miRNA
regulation of posttranscriptional gene silencing
regulation of gene silencing by RNA
DNA-templated transcription, elongation
ncRNA transcription
positive regulation of viral process
cellular response to fibroblast growth factor stimulus
nucleotide-excision repair
response to fibroblast growth factor
regulation of type I interferon production
regulation of gene silencing
stem cell population maintenance
maintenance of cell number
transcription initiation from RNA polymerase II promoter