POLR2K

Entrez Summary: This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008].
UniProt Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 2μM R00 exp25	-1.88
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.83
proTAME 5μM R04 exp187	1.71
BI-2536 0.001μM R01 exp41	1.78
LJH685 5μM R02 exp73	1.78
Glyphosate 1000μM R06 exp283	1.81
GSK343 3μM R03 exp124	1.82
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.88
Taxol 0.002μM R01 exp54	1.9
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.98
Lapatinib 5μM R01 exp47	2.04
2-Methoxyestradiol 0.2μM R01 exp40	2.19
Nicotinamide 2000μM R01 exp50	2.23

Global Fraction of Cell Lines Where Essential: 628/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	27/28
bone	22/25
breast	24/33
central nervous system	50/56
cervix	3/4
colorectal	14/17
esophagus	11/13
fibroblast	1/1
gastric	11/15
kidney	19/21
liver	17/20
lung	67/75
lymphocyte	14/14
ovary	23/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	22/24
soft tissue	6/7
thyroid	2/2
upper aerodigestive	15/22
urinary tract	24/29
uterus	4/5

Expression Distribution

RNA polymerase II activity
RNA polymerase I activity
RNA polymerase I complex
RNA polymerase II, core complex
RNA polymerase III activity
RNA polymerase III complex
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
regulation of transcription by RNA polymerase I
7-methylguanosine mRNA capping
7-methylguanosine RNA capping
RNA capping
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
positive regulation of viral transcription
transcription by RNA polymerase III
positive regulation of gene expression, epigenetic
regulation of viral transcription
somatic stem cell population maintenance
snRNA transcription by RNA polymerase II
snRNA transcription
DNA-templated transcription, termination
transcription-coupled nucleotide-excision repair
transcription elongation from RNA polymerase II promoter
positive regulation of type I interferon production
fibroblast growth factor receptor signaling pathway
regulation of gene silencing by miRNA
regulation of gene silencing by RNA
regulation of posttranscriptional gene silencing
DNA-templated transcription, elongation
ncRNA transcription
positive regulation of viral process
cellular response to fibroblast growth factor stimulus
nucleotide-excision repair
response to fibroblast growth factor
regulation of type I interferon production
regulation of gene silencing
stem cell population maintenance
maintenance of cell number
transcription initiation from RNA polymerase II promoter