POP5

Entrez Summary: N/A
UniProt Summary: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. {ECO:0000269|PubMed:11413139}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0129480 7μM R02 exp85	-2.13
Amiloride 100μM R08 exp447	-1.83
Mubritinib 0.2μM R02 exp65	1.71
Nicotinamide Riboside 100μM R03 exp139	1.8
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	2.08
Fluvastatin 2.2μM R06 exp282	2.34

Global Fraction of Cell Lines Where Essential: 730/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	31/33
central nervous system	55/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	0/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	4/5

Expression Distribution

Gene	Correlation
RPL35	0.452
RRM1	0.443

nucleolar ribonuclease P complex
ribonuclease MRP complex
multimeric ribonuclease P complex
ribonuclease P RNA binding
ribonuclease P activity
tRNA 5-leader removal
tRNA 5-end processing
ncRNA 5-end processing
RNA 5-end processing
RNA phosphodiester bond hydrolysis, endonucleolytic
tRNA processing
RNA phosphodiester bond hydrolysis
tRNA metabolic process
rRNA processing
rRNA metabolic process
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA metabolic process
gene expression