PRKG2

Entrez Summary: N/A
UniProt Summary: Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). {ECO:0000250|UniProtKB:Q61410, ECO:0000250|UniProtKB:Q64595}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
S-DABN 8μM R03 exp112	-1.81
Isonicotinamide 500μM R03 exp129	1.7
PF-06409577 20μM R07 exp389	1.71
SB202190 10μM R03 exp148	1.72
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.75
CB-5083 0.4μM R08 exp468	1.76
Ibrutinib 1μM R07 exp372	1.86
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	2
Palbociclib 1μM R07 exp382	2.06
Golgicide-A 4μM R03 exp122	2.12
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.24
Dexamethasone 0.006μM R07 exp351	2.29
PT-1 25μM R07 exp392	2.76

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cGMP-dependent protein kinase activity
negative regulation of chloride transport
peptidyl-serine autophosphorylation
regulation of chloride transport
cAMP-dependent protein kinase activity
cAMP-dependent protein kinase complex
cGMP binding
negative regulation of anion transport
regulation of anion transport
negative regulation of ion transport
peptidyl-serine phosphorylation
protein localization to plasma membrane
protein autophosphorylation
peptidyl-serine modification
protein localization to cell periphery
protein kinase activity
nuclear membrane
apical plasma membrane
cofactor metabolic process
protein localization to membrane
negative regulation of transport
regulation of ion transport
protein homodimerization activity
peptidyl-amino acid modification
protein phosphorylation
phosphorylation
ATP binding
cellular protein localization
cellular macromolecule localization
regulation of transport