PRPF3

Entrez Summary: The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. This gene product is one of several proteins that associate with U4 and U6 snRNPs. Mutations in this gene are associated with retinitis pigmentosa-18. [provided by RefSeq, Jul 2008].
UniProt Summary: Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. {ECO:0000269|PubMed:9328476, ECO:0000269|PubMed:9404889, ECO:0000303|PubMed:20595234}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Salinomycin 3.5μM R08 exp521	-1.81
Diepoxybutane 3μM R07 exp354	-1.75
Methotrexate 0.01μM R08 exp501	1.74
YM155 0.0002μM R01 exp61	1.79
Betulinic acid 10 to 15μM on day4 R05 exp222	1.83
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.83
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.84
2-Deoxy-D-glucose 800μM R05 exp214	1.92

Global Fraction of Cell Lines Where Essential: 377/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	12/28
blood	21/28
bone	9/26
breast	15/33
central nervous system	20/56
cervix	1/4
colorectal	9/17
esophagus	6/13
fibroblast	0/1
gastric	9/16
kidney	9/21
liver	10/20
lung	39/75
lymphocyte	11/16
ovary	14/26
pancreas	16/24
peripheral nervous system	9/16
plasma cell	9/15
prostate	1/1
skin	10/24
soft tissue	5/9
thyroid	2/2
upper aerodigestive	14/22
urinary tract	12/29
uterus	2/5

Expression Distribution

spliceosomal tri-snRNP complex assembly
U4/U6 x U5 tri-snRNP complex
spliceosomal snRNP assembly
U2-type precatalytic spliceosome
Cajal body
spliceosomal complex
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
cellular protein-containing complex assembly
RNA processing
identical protein binding
RNA binding
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression