RALB

Gene Information
  • Official Symbol: RALB
  • Official Name: RAS like proto-oncogene B
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 5899
  • UniProt: P11234
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269). {ECO:0000250|UniProtKB:P36860, ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 18256
  • Expression level (log2 read counts): 4.87

Expression Distribution

  • Last modified: 2026/01/07 22:36
  • by 127.0.0.1