RAP1B
Gene Information
- Official Symbol: RAP1B
- Official Name: RAP1B, member of RAS oncogene family
- Aliases and Previous Symbols: N/A
- Entrez ID: 5908
- UniProt: P61224
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Miro |
| Arf |
| GTP EFTU |
| Ras |
GO Terms
| negative regulation of synaptic vesicle exocytosis |
| cellular response to gonadotropin-releasing hormone |
| negative regulation of calcium ion-dependent exocytosis |
| response to gonadotropin-releasing hormone |
| Rap protein signal transduction |
| negative regulation of neurotransmitter secretion |
| microvillus assembly |
| microvillus organization |
| regulation of establishment of cell polarity |
| negative regulation of neurotransmitter transport |
| regulation of establishment or maintenance of cell polarity |
| negative regulation of regulated secretory pathway |
| establishment of endothelial barrier |
| negative regulation of exocytosis |
| regulation of calcium ion-dependent exocytosis |
| interleukin-12-mediated signaling pathway |
| cellular response to interleukin-12 |
| response to interleukin-12 |
| endothelial cell development |
| cellular response to cAMP |
| azurophil granule membrane |
| negative regulation of synaptic transmission |
| GDP binding |
| regulation of synaptic vesicle exocytosis |
| lipid droplet |
| endothelial cell differentiation |
| intracellular |
| regulation of cell junction assembly |
| endothelium development |
| response to cAMP |
| regulation of neurotransmitter secretion |
| regulation of synaptic vesicle cycle |
| response to organophosphorus |
| regulation of neurotransmitter transport |
| response to purine-containing compound |
| regulation of regulated secretory pathway |
| cell-cell junction |
| response to carbohydrate |
| epithelial cell development |
| negative regulation of secretion by cell |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of exocytosis |
| membrane raft |
| negative regulation of secretion |
| Ras protein signal transduction |
| protein-containing complex binding |
| cellular response to peptide hormone stimulus |
| regulation of ERK1 and ERK2 cascade |
| small GTPase mediated signal transduction |
| cellular response to peptide |
| GTPase activity |
| regulation of neurotransmitter levels |
| GTP binding |
| response to peptide hormone |
| cellular response to drug |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| plasma membrane bounded cell projection assembly |
| cell projection assembly |
| response to peptide |
| negative regulation of transport |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| regulation of vesicle-mediated transport |
| cell population proliferation |
| myeloid leukocyte activation |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| cellular response to nitrogen compound |
| cytokine-mediated signaling pathway |
| epithelial cell differentiation |
| regulated exocytosis |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| leukocyte mediated immunity |
| exocytosis |
| regulation of secretion |
| response to hormone |
| regulation of cellular localization |
| response to organic cyclic compound |
| leukocyte activation |
| regulation of cellular component biogenesis |
| response to organonitrogen compound |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| export from cell |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| response to cytokine |
| epithelium development |
| plasma membrane bounded cell projection organization |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| cell development |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| 2-Deoxy-D-glucose 800μM R05 exp214 | -1.7 |
| BI-6727 0.0125μM R03 exp97 | 1.73 |
| BI-6727 0.001μM R01 exp42 | 1.92 |
| LJH685 5μM R02 exp73 | 2.2 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8930
- Expression level (log2 read counts): 6.57
Expression Distribution
RAP1B Expression in NALM6 Cells: 6.57
