RAP1GDS1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-2.17
Pimelic-diphenylamide-106 0.5μM R00 exp27	-1.73
Amiloride 100μM R08 exp447	1.72

Arm
V-ATPase H N

negative regulation of endoplasmic reticulum calcium ion concentration
positive regulation of mitochondrial calcium ion concentration
myosin filament assembly
myosin filament organization
vascular smooth muscle contraction
endoplasmic reticulum calcium ion homeostasis
mitochondrial calcium ion homeostasis
vasoconstriction
negative regulation of blood vessel diameter
smooth muscle contraction
regulation of tube diameter
regulation of blood vessel diameter
regulation of tube size
vascular process in circulatory system
muscle contraction
GTPase activator activity
muscle system process
blood circulation
circulatory system process
positive regulation of GTPase activity
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
regulation of GTPase activity
divalent inorganic cation homeostasis
actin cytoskeleton organization
regulation of anatomical structure size
cellular metal ion homeostasis
actin filament-based process
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
positive regulation of hydrolase activity
ion homeostasis
cellular protein-containing complex assembly
cellular homeostasis
endoplasmic reticulum