RAPGEF4

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:9856955}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ras GTPase binding
Ras guanyl-nucleotide exchange factor activity
cAMP binding
hippocampal mossy fiber to CA3 synapse
insulin secretion
calcium-ion regulated exocytosis
peptide hormone secretion
hormone secretion
hormone transport
guanyl-nucleotide exchange factor activity
regulation of synaptic vesicle cycle
cAMP-mediated signaling
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
signal release
cyclic-nucleotide-mediated signaling
peptide secretion
regulation of insulin secretion
regulation of peptide hormone secretion
regulation of exocytosis
regulation of hormone secretion
small GTPase mediated signal transduction
second-messenger-mediated signaling
regulation of protein secretion
regulation of peptide secretion
regulation of hormone levels
regulation of vesicle-mediated transport
regulated exocytosis
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
exocytosis
regulation of secretion
regulation of cellular localization
secretion by cell
regulation of protein localization
export from cell
cell-cell signaling