RNF7

Entrez Summary: N/A
UniProt Summary: Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. {ECO:0000250|UniProtKB:P62877, ECO:0000269|PubMed:10851089}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UNC1999 2μM R03 exp155	-2.22
Milciclib 2μM R08 exp502	-2
Ethanol 0.01 R05 exp234	-1.92
AICAR 240μM R03 exp116	-1.7
YM155 0.001μM R08 exp432	1.83
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.07
39°C R06 exp303	2.08

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-Apc11
zf-rbx1

nuclear SCF ubiquitin ligase complex
Cul7-RING ubiquitin ligase complex
NEDD8 transferase activity
Cul5-RING ubiquitin ligase complex
cullin-RING ubiquitin ligase complex
protein neddylation
response to redox state
Cul2-RING ubiquitin ligase complex
cullin family protein binding
Cul4-RING E3 ubiquitin ligase complex
Cul3-RING ubiquitin ligase complex
copper ion binding
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
ubiquitin protein ligase activity
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
post-translational protein modification
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
zinc ion binding
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
organic substance catabolic process
cellular catabolic process