RPP30

Entrez Summary: N/A
UniProt Summary: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 637/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	24/28
blood	23/28
bone	22/26
breast	26/33
central nervous system	53/56
cervix	3/4
colorectal	12/17
esophagus	12/13
fibroblast	1/1
gastric	13/16
kidney	17/21
liver	17/20
lung	68/75
lymphocyte	16/16
ovary	22/26
pancreas	22/24
peripheral nervous system	13/16
plasma cell	13/15
prostate	0/1
skin	20/24
soft tissue	7/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	26/29
uterus	5/5

Expression Distribution

Screen	Score
Chloramphenicol 2μM R00 exp12	-2.66
Pimelic-diphenylamide-106 0.5μM R00 exp27	-2.46
Mdivi-1 15μM R05 exp217	-1.8

nucleolar ribonuclease P complex
ribonuclease MRP complex
multimeric ribonuclease P complex
ribonuclease P RNA binding
ribonuclease P activity
tRNA 5-leader removal
tRNA 5-end processing
ncRNA 5-end processing
RNA 5-end processing
RNA phosphodiester bond hydrolysis, endonucleolytic
tRNA processing
RNA phosphodiester bond hydrolysis
tRNA metabolic process
rRNA processing
rRNA metabolic process
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
RNA processing
RNA binding
RNA metabolic process
gene expression