RSL1D1

Entrez Summary: N/A
UniProt Summary: Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 706/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	24/28
blood	27/28
bone	26/26
breast	30/33
central nervous system	56/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	19/20
lung	73/75
lymphocyte	14/16
ovary	21/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	28/29
uterus	5/5

Expression Distribution

90S preribosome
maturation of LSU-rRNA
mRNA 5-UTR binding
regulation of cellular senescence
regulation of cell aging
ribosomal large subunit biogenesis
mRNA 3-UTR binding
osteoblast differentiation
rRNA processing
rRNA metabolic process
ossification
ribosome biogenesis
cadherin binding
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
regulation of cellular response to stress
nucleolus
RNA processing
regulation of protein localization
RNA binding
regulation of response to stress
regulation of apoptotic process
regulation of programmed cell death
RNA metabolic process
regulation of cell death
membrane
gene expression