RYBP

Gene Information

Official Symbol: RYBP
Official Name: RING1 and YY1 binding protein
Aliases and Previous Symbols: N/A
Entrez ID: 23429
UniProt: Q8N488
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). {ECO:0000250|UniProtKB:Q8CCI5, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:27060496}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6

Essentiality Rank: 18795
Expression level (log2 read counts): 5.12

Expression Distribution

Screen	Score
Resveratrol 16μM R03 exp147	-1.91
Actinomycin-D 0.01μM R00 exp4	-1.86
Pterostilbene 16μM R02 exp78	-1.81
Rotenone 20μM R00 exp34	-1.71

histone H2A monoubiquitination
histone H2A ubiquitination
PcG protein complex
histone monoubiquitination
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of G0 to G1 transition
histone ubiquitination
regulation of G0 to G1 transition
negative regulation of ubiquitin-dependent protein catabolic process
negative regulation of proteasomal protein catabolic process
protein monoubiquitination
negative regulation of proteolysis involved in cellular protein catabolic process
negative regulation of cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
transcription corepressor activity
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
negative regulation of catabolic process
negative regulation of cell cycle process
negative regulation of proteolysis
histone modification
covalent chromatin modification
regulation of protein catabolic process
negative regulation of cell cycle
positive regulation of apoptotic process
positive regulation of programmed cell death
protein ubiquitination
positive regulation of cell death
chromatin organization
regulation of proteolysis
regulation of cell cycle process
protein modification by small protein conjugation
regulation of cellular catabolic process
negative regulation of transcription by RNA polymerase II
apoptotic process
protein modification by small protein conjugation or removal