SBNO2

Gene Information

Official Symbol: SBNO2
Official Name: strawberry notch homolog 2
Aliases and Previous Symbols: N/A
Entrez ID: 22904
UniProt: Q9Y2G9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A

UniProt Summary: Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP- repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11RANKL-mediated osteoclast fusion via a DCSTAMP- dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162). Plays a role as a regulator in the proinflammatory cascade (PubMed:18025162). {ECO:0000250|UniProtKB:Q7TNB8, ECO:0000269|PubMed:18025162}. Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.

GO Terms

cellular response to interleukin-11

response to interleukin-11

osteoclast fusion

multinuclear osteoclast differentiation

bone trabecula morphogenesis

macrophage activation involved in immune response

cellular response to interleukin-6

cell-cell fusion

response to interleukin-6

syncytium formation by plasma membrane fusion

syncytium formation

osteoclast differentiation

trabecula morphogenesis

bone mineralization

macrophage activation

biomineralization

biomineral tissue development

response to leukemia inhibitory factor

cellular response to leukemia inhibitory factor

myeloid leukocyte differentiation

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin

cellular response to biotic stimulus

myeloid cell differentiation

ossification

response to lipopolysaccharide

response to molecule of bacterial origin

leukocyte differentiation

regulation of inflammatory response

cellular component

cellular response to lipid

myeloid cell activation involved in immune response

hemopoiesis

myeloid leukocyte activation

hematopoietic or lymphoid organ development

leukocyte activation involved in immune response

cell activation involved in immune response

immune system development

response to bacterium

regulation of defense response

response to lipid

anatomical structure formation involved in morphogenesis

leukocyte activation

cellular response to cytokine stimulus

cellular response to oxygen-containing compound

cell activation

immune effector process

regulation of response to external stimulus

response to cytokine

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

negative regulation of nucleic acid-templated transcription

negative regulation of RNA biosynthetic process

response to other organism

response to external biotic stimulus

response to biotic stimulus

negative regulation of RNA metabolic process

negative regulation of cellular macromolecule biosynthetic process

negative regulation of nucleobase-containing compound metabolic process

negative regulation of macromolecule biosynthetic process

regulation of response to stress

negative regulation of cellular biosynthetic process

positive regulation of transcription, DNA-templated

negative regulation of biosynthetic process

response to oxygen-containing compound

positive regulation of nucleic acid-templated transcription

positive regulation of RNA biosynthetic process

negative regulation of gene expression

positive regulation of RNA metabolic process

tissue development

immune response

positive regulation of nucleobase-containing compound metabolic process

positive regulation of macromolecule biosynthetic process

positive regulation of cellular biosynthetic process

positive regulation of gene expression

positive regulation of biosynthetic process

=== CRISPR Data === Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit

Screen Score

Pterostilbene 16μM R02 exp78 -2.13

AICAR 240μM R03 exp116 -1.85

SGC0946 7μM R03 exp151 -1.73

TRAIL 5ng/ml R00 exp35 1.84

TRAIL 50ng/ml R00 exp36 1.94

PF-06409577 20μM R07 exp389 1.97

Benzoate 10000μM R08 exp455 2.2

Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.

Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739

Tissue Fraction Of Cell Lines Where Essential

1290807.0 0/1

909776.0 0/1

bile duct 0/28

blood 0/28

bone 0/26

breast 0/33

central nervous system 0/56

cervix 0/4

colorectal 0/17

esophagus 0/13

fibroblast 0/1

gastric 0/16

kidney 0/21

liver 0/20

lung 0/75

lymphocyte 2/16

ovary 0/26

pancreas 0/24

peripheral nervous system 0/16

plasma cell 0/15

prostate 0/1

skin 0/24

soft tissue 0/9

thyroid 0/2

upper aerodigestive 0/22

urinary tract 0/29

uterus 0/5

== Essentiality in NALM6 == * Essentiality Rank: 6316 * Expression level (log2 read counts): 5.71 Expression Distribution
SBNO2 Expression in NALM6 Cells: 5.71

Screen	Score
Pterostilbene 16μM R02 exp78	-2.13
AICAR 240μM R03 exp116	-1.85
SGC0946 7μM R03 exp151	-1.73
TRAIL 5ng/ml R00 exp35	1.84
TRAIL 50ng/ml R00 exp36	1.94
PF-06409577 20μM R07 exp389	1.97
Benzoate 10000μM R08 exp455	2.2

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5