SCN9A

Entrez Summary: This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sodium ion binding
voltage-gated sodium channel complex
behavioral response to pain
voltage-gated sodium channel activity
neuronal action potential
membrane depolarization during action potential
response to pain
voltage-gated ion channel activity
membrane depolarization
transmission of nerve impulse
multicellular organismal response to stress
sensory perception of pain
post-embryonic development
sodium ion transmembrane transport
action potential
multicellular organismal signaling
sodium ion transport
axon
monovalent inorganic cation transport
regulation of membrane potential
regulation of ion transmembrane transport
inflammatory response
response to toxic substance
inorganic cation transmembrane transport
regulation of transmembrane transport
behavior
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
regulation of ion transport
cation transport
ion transmembrane transport
sensory perception
transmembrane transport
defense response
ion transport
nervous system process
integral component of plasma membrane
regulation of transport
system process