SENP5

Entrez Summary: N/A
UniProt Summary: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. {ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.001μM R01 exp42	-2.07
Nicotinamide 1000μM R03 exp101	-1.8
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.78
LLY-283 2.6μM R06 exp290	-1.73
CAY10603 0.55μM R08 exp467	1.78

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ubiquitin-like protein-specific protease activity
protein desumoylation
protein sumoylation
protein modification by small protein removal
peptidyl-lysine modification
cell division
protein modification by small protein conjugation
nucleolus
peptidyl-amino acid modification
protein modification by small protein conjugation or removal
proteolysis
cell cycle