SF1

Entrez Summary: This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I1 10μM R06 exp256	-1.93
Deferoxamine 11μM R07 exp350	-1.8
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.71
Chloramphenicol 2μM R00 exp12	1.78
Dimethyloxaloylglycine 11μM R07 exp314	1.93
Pyridostatin 4μM R05 exp240	1.99
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.2
ML-792 0.2μM R08 exp505	2.46
MS023 7μM R03 exp135	2.59
ZLN024 50μM R08 exp538	2.59
CR131-b 0.005μM R08 exp474	3.33
MS023 2μM R03 exp134	3.71

Global Fraction of Cell Lines Where Essential: 726/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/25
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	14/14
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

pre-mRNA branch point binding
mRNA 3-splice site recognition
Leydig cell differentiation
male sex determination
nuclear body organization
sex determination
mRNA splice site selection
ribosome
negative regulation of smooth muscle cell proliferation
spliceosomal complex assembly
regulation of steroid biosynthetic process
spliceosomal complex
regulation of steroid metabolic process
regulation of smooth muscle cell proliferation
nucleus organization
male gonad development
development of primary male sexual characteristics
male sex differentiation
regulation of lipid biosynthetic process
gonad development
development of primary sexual characteristics
ribonucleoprotein complex assembly
transcription corepressor activity
ribonucleoprotein complex subunit organization
sex differentiation
nuclear body
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
regulation of lipid metabolic process
RNA splicing
reproductive structure development
reproductive system development
ribonucleoprotein complex biogenesis
mRNA processing
developmental process involved in reproduction
negative regulation of cell population proliferation
mRNA metabolic process
zinc ion binding
cellular protein-containing complex assembly