SIN3B

Entrez Summary: N/A
UniProt Summary: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. {ECO:0000250|UniProtKB:Q62141}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK461364A 0.005μM R03 exp125	-2.65
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-2.28
Pomalidomide 20μM R07 exp391	-2.18
Caffeine 2600μM R08 exp463	-2.06
CHIR-124 0.04μM R06 exp272	-2.05
ONC212 0.15μM R08 exp513	1.72
Ammonium tetrathiomolybdate 10μM R08 exp448	1.77
PU-H71 1μM R08 exp515	1.81
TIC10 10μM R08 exp532	1.81
JQ1 0.8μM R08 exp435	1.85

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

HDAC interact
PAH

autosome
Y chromosome
X chromosome
XY body
Sin3 complex
histone deacetylase activity
histone deacetylation
protein deacetylation
protein deacylation
macromolecule deacylation
chromatin
transcription corepressor activity
histone modification
covalent chromatin modification
chromatin binding
regulation of lipid metabolic process
chromatin organization
negative regulation of transcription by RNA polymerase II
chromosome organization
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression