SLC23A2

Entrez Summary: The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008].
UniProt Summary: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

L-ascorbic acid transmembrane transport
L-ascorbate:sodium symporter activity
sodium-dependent L-ascorbate transmembrane transporter activity
nucleobase transmembrane transporter activity
transepithelial L-ascorbic acid transport
L-ascorbic acid transmembrane transporter activity
coenzyme transport
nucleobase transport
L-ascorbic acid metabolic process
vitamin transmembrane transport
transepithelial transport
basal plasma membrane
monosaccharide transmembrane transport
carbohydrate transmembrane transport
vitamin transport
transporter activity
cofactor transport
carbohydrate transport
water-soluble vitamin metabolic process
vitamin metabolic process
organic acid transmembrane transport
carboxylic acid transmembrane transport
sodium ion transport
basolateral plasma membrane
monosaccharide metabolic process
coenzyme metabolic process
anion transmembrane transport
carboxylic acid transport
organic acid transport
apical plasma membrane
response to oxidative stress
monovalent inorganic cation transport
cofactor metabolic process
organic anion transport
carbohydrate metabolic process
anion transport
metal ion transport
cation transport
carboxylic acid metabolic process
ion transmembrane transport